Pediatric Infectious Disease Questions

A 1-year-old boy presents with recurrent otitis media, pneumonitis, and sinusitis. The physical examination reveales bilateral otitis media, but no cervical lymph nodes are palpable and the tonsils are not visible. This picture is most compatible with a picture of:
a. Selective IgA deficiency
b. Chronic granulomatous disease
c. DiGeorge syndrome
d. X-linked agammaglobulinemia
e. C2 complement definciency


The triad of eczema, thrombocytopenia, and recurrent infections is characteristic of:
a. Chediak-Higashi syndrome
b. Wiskott-Aldrich syndrome
c. Common variable hypogammaglobulinemia
d. Hyper-IgE syndrome
e. Adenosine deaminase deficiency

A 2-year-old boy presents with a history of protracted lymphadenitis, cavitary pneumonitis, and organomegaly. The single best test to diagnose his immunodeficiency is:
a. CH50
b. Quantitative immunoglobulin measurement
c. Isohemagglutinin titers
d. Delayed hypersensitivity skin testing
e. Nitroblue tetrazolium dye reduction test

Infusions of interferon-gamma are especially helpful for patients with:
a. Hyper-IgM syndrome
b. Ataxia-telangiectasia
c. Chronic granulomatous disease
d. Severe combined immunodeficiency
e. Leukocyte adherence deficiency

The best screening test for immunodeficiency in a patient after her second episode of meningococcal meningitis is:
a. Quantitative immunoglobulin measurement
b. CH50
c. Determination of T-cell subsets
d. Determination of IgG subclasses
e. Nitroblue tetrazolium dye reduction test

Your patient requires a blood transfusion. In which condition must the blood be irradiated?
a. Chronic granulomatous disease
b. DiGeorge syndrome
c. X-linked agammaglobulinemia
d. Selective IgA deficiency
e. C3 deficiency